【摘 要】
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Oxalate is a highly toxic molecule that contains an unreactive C-C bond and has a half-life of approximately 10,000 years [1].Biology has evolved three solutions to the problem of catalyzing the break
【机 构】
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Department of Chemistry & Chemical Biology,Indiana University Purdue University Indianapolis,402 N.B
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
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Oxalate is a highly toxic molecule that contains an unreactive C-C bond and has a half-life of approximately 10,000 years [1].Biology has evolved three solutions to the problem of catalyzing the breakdown of oxalate [2],including thiamin-dependent decarboxylation of the thioester derivative in bacteria [3].Fungi and some soil bacteria,however,employ the manganese-dependent enzyme oxalate decarboxylase [4] to convert oxalate into carbon dioxide and formate via a mechanism about which little is definitively known.
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