Sphingosine-1-phosphate ameliorates left ventricular remodeling and dysfunction after myocardial inf

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户:a263537545
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Background: Sphingosine-1-phosphate(S1P)/S1P receptor 1 signaling has received attention for its potential to ameliorate myocardial ischemia-reperfusion injury.However,little is known about the effect of S1P administration in cardiac remodeling after myocardial infarction(MI).
其他文献
Objective: Renal tubulointerstitial fibrosis is the common and final pathologic change of kidney in end-stage renal disease.Interesting,Our previous study indicated endoplasmic reticulum(ER)stress is
Background: The mitotic arrest deficient protein MAD2B is a well-defined anaphase-promoting complex/cyclosome(APC/C)inhibitor and a small subunit of DNA polymerase zeta.It is critical for mitotic cont
Background: Interleukin 6(IL-6)is a pleiotropic cytokine that has both pro-and anti-inflammatory properties via the membrane bound IL-6R(classical IL-6 signaling)or the soluble IL-6R(IL-6 trans-signal
Introduction: Tubulointerstitial fibrosis(TIF)is the common feature and the final event of chronic kidney diseases,which is characterized by extracellular matrix(ECM)deposition in association with tub
Objectives: A major complication related to colonic dysmotility in diabetic patients is slow transit constipation,but little is known about the mechanism.PDGFRα+(Platelet—derived growth factor recept
Early aspects of the pathogenesis of the vascular complications of type 2 diabetes mellitus(T2DM)include upregulation of the proinflammatory cytokines,like tumor necrosis factor-alpha(TNF-α),interleuk
Objectives: It is generally considered that enteric neuropathy is one of the causative factors of diabetic gastroparesis.Our previous study demonstrated that there is a loss of NOS neurons in diabetic
GPR120 is member of free fatty acid(FFA)receptors,and its defect leads to metabolic diseases such as obesity.A series of non-FFA agonists for GPR120 were reported,and it is reported that grifolic acid
会议
Vascular hyporeactivity is one of the major causes responsible for refractory hypotension and associated mortality in vascular hypoxemia disease.Mitochondrial permeability transition(MPT)pore opening
Objective: Essential hypertension is a common cardiovascular disease and its cause remains unknown.It is established that sympathetic nerve overactivity is the most important cause but it is unclear w