Purpose: This study assesses and compares the quality of life of oral cancer patients who had undergone surgical resection and primary reconstruction of defect using either radial forearm free flap(RFFF)or pectoralis major myocutaneous flap(PMMF).Methods: The University of Washington of life(UW-QOL v4)questionnaire was mailed to patients who had disease free survival for at least one year.Patients demographic and quality of life data were collected and analyzed.Results: A total of 112 questionnaires were returned(51.61%).There were significant differences in Tstage(p=0.002),surgical time(p=0.01)and duration if hospitalization(p<0.001)between the two groups.Patients reconstructed with RFFF had better speech,shoulder and mood domain,while swallowing in total/subtotal glossectomy was better in PMMF group.Conclusion: Data from this study serve as a useful resource for physicians and patients during their discussion of reconstructive options for oral cancer.