【摘 要】
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Aim The present study was aimed to investigate the anti-inflammatory effect and the possible mechanism of protocatechuic aldehyde (PAI) on MI/R injury both in vivo and in vitro.Methods Pretreatment wi
【机 构】
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Department of Pharmacy, Xijing Hospital, Fourth Military Medical University 710032
【出 处】
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中华医学会临床药学分会2014年全国学术会议
论文部分内容阅读
Aim The present study was aimed to investigate the anti-inflammatory effect and the possible mechanism of protocatechuic aldehyde (PAI) on MI/R injury both in vivo and in vitro.Methods Pretreatment with PAI could protect the heart from MI/R injury by reducing myocardial infarct size and the activities of creatine kinase-MB (CK-MB) and cardiac troponin I (cTn-I) in serum.Also, PAI administration markedly reduced cellular injury induced by simulated ischemia/reperfusion (SI/R) in cultured neonatal rat cardiomyocytes.
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