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HOX基因簇基因编码调控生物发育过程模式形成的重要转录因子,其在脊椎动物中呈现严格的时空共线性表达的特征.在胚胎干细胞中,HOX基因簇处于双价染色体(bivalent chromatin)区域,即同时包含MLL复合物介导的H3K4me3修饰和PRC复合物介导的H3K27me3修饰.
胚胎干细胞特异的长链非编码RNA参与沉默HOXA基因簇
【摘 要】
：
HOX基因簇基因编码调控生物发育过程模式形成的重要转录因子,其在脊椎动物中呈现严格的时空共线性表达的特征.在胚胎干细胞中,HOX基因簇处于双价染色体(bivalent chromatin)
【机 构】
：
北京协和医学院医学分子生物学国家重点实验室
【出 处】
：
中国细胞生物学学会2013年全国学术大会
【发表日期】
：
2013年4期
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