目的 The purpose of the study is to observe the capacity of progesterone(PROG)to reverse the corticosteroid insensitivity and todetect its synergistic effects with glucocorticoids in protecting against the inflammation.方法 male C57/BL6 mice are divided into 4 parts as follows：O3+normal saline,O3+BUD,O3+BUD+low PROG and O3+BUD+high PROG.Mice were killed for the mean linear intercept and airway inflammatory cells infiltration density and measurement ofthe numbers of inflammation cells and the inflammatory cytokines of bronchoalveolar lavage fluid(BALF),serum and lung tissuecollection to examine the expression of the inflammatory cytokines,NF-κB,glucocorticoids receptors(GR)and p38MAPK.