Pro-apoptotic and anti-proliferative effects of mitofusin-2 via PI3K/Akt signaling in breast cancer

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户:bluebirdmengmeng
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Mitochondrial GTPase mitofusin-2 gene (Mfn2) is a novel gene characterized as a cell proliferation inhibitor.Recently, Mfn2 has been reported to have a potential role in regulating cell proliferation, apoptosis, and differentiation in many cell types.However, there is no report on the effect of Mfn2 on breast cancer.In this study, we sought to investigate the function and mechanism of Mfn2 in breast cancer.Plasmid encoding the complete Mfn2 open reading frame (pEGFP-Mfn2)was used to infect breast cancer cells.
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