【摘 要】
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Gene therapy shows much promise in tackling various genetic diseases and cancers,viral infection,and cardiovascular disorders.The most challenging task in g
【机 构】
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CollegeofMaterialsScience&Engineering,BeijingUniversityofChemicalTechnology,Beijing100029China
【出 处】
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中国科协第282次青年科学家论坛——化学与生物和能源的交叉与融合
论文部分内容阅读
Gene therapy shows much promise in tackling various genetic diseases and cancers,viral infection,and cardiovascular disorders.The most challenging task in gene therapy is the design of efficient gene delivery vectors.Recent progress in living/controlled radical polymerizations(LRPs),in particular atom transfer radical polymerization(ATRP),has provided a unique means for the design and synthesis of new polymeric gene vectors with well-defined composition,architecture and functionality.The recent research activities indicate that ATRP has become essential tools for the design and synthesis of advanced,noble and novel gene carriers.More recently,our group has successfully employed ATRP for the design of series of new polysaccharide-based gene vectors.1-10 The approach to well-defined polymeric vectors via ATRP provides a versatile means for tailoring the structure of non-viral gene vectors to meet the requirements on low cytotoxicity,good stability and high transfection efficiency for gene therapy applications.
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