【摘 要】
：
The IKs channel is found in cardiac muscle cells and in some neurons.The major function of the IKs channel is to terminate cardiac action potentials and thus maintain a proper heart rhythm.Mutations i
【机 构】
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Washington University USA
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
The IKs channel is found in cardiac muscle cells and in some neurons.The major function of the IKs channel is to terminate cardiac action potentials and thus maintain a proper heart rhythm.Mutations in the IKs channel protein that reduce its expression or alter its function have been associated with atrial fibrillation and the long Q-T syndrome (LQT),which causes syncope and sudden death in patents.The IKs channel is comprised of two kinds of subunits,KCNQ 1 and KCNE 1.In the study of an LQT-associated mutation in KCNQ 1,we found that the mutation disrupts electrostatic interactions between the S2 and the S4 transmembrane segments in the voltage sensor domain of the channel.These electrostatic interactions determine voltage dependent activation of the channel and are crucial for IKs channel function.We found that extracellular reagents can modify the electrostatic interactions in the IKs channel to either enhance or reduce channel function.
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