Quartz crystal microbalance (QCM) immunosensor exhibits extremely high detection sensitivity for biological macromolecules [1].To implement a QCM immunosensor, antibody or antigen needs to be immobilized on the crystal surface to capture target molecules.However, most times antigens or antibodies were either expensive or difficult to generate.Also, some antibodies were very sensitive to environment and their binding affinities would decrease after immobilization.So, the development of small ligands with high binding affinity and low cost is of great interest.Antisense peptides are defined as the sequences of amino acids encoded by the antisense strand of DNA [2].It is shown that antisense peptides can bind to sense peptides or proteins with significant selectivity and affinity [3].