【摘 要】
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Small interfering RNA (siRNA) has been rapidly developed as a promising candidate for treatment of numerous diseases.However,clinicalapplication of RNA interfer
【出 处】
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第五届中国小核酸技术与应用学术会议
论文部分内容阅读
Small interfering RNA (siRNA) has been rapidly developed as a promising candidate for treatment of numerous diseases.However,clinicalapplication of RNA interference is limited by the delivery of siRNA in vivo.We have developed nanoparticle system with stealthy property for efficient siRNA encapsulation and delivery,which is fabricated with poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PLA),siRNA and a cationic lipid,using a double emulsion-solvent evaporation technique.Such formulation exhibited high encapsulation efficiency of siRNA,significant down-regulation of gene expression in vivo,and was used for anti-tumor treatments.
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