【摘 要】
：
Gap junctions (G J) play an important role in intercellular communication between adjacent cells.The protein expression, membrane cluster, subtype couple, pore selectivity and gating of GJs might be r
【机 构】
：
College of Life Sciences & Research Center for Peptide Drugs, Yanan University, Yanan 716000,China;S
【出 处】
：
第12届生物毒素研究及医药应用学术大会
论文部分内容阅读
Gap junctions (G J) play an important role in intercellular communication between adjacent cells.The protein expression, membrane cluster, subtype couple, pore selectivity and gating of GJs might be regulated by phosphorylation of connexins.
其他文献
芋螺毒素(CTx)是一大类来源于芋螺毒管中的活性多肽.在我国，芋螺是海南特有的热带药用海洋生物资源，极具开发价值.CTx通常含有10～46个氨基酸，富含二硫键，生物活性强，能特异地作用于动物细胞膜上的受体和离子通道.其中的α-芋螺毒素是烟碱型乙酰胆碱受体(nAChRs)特异阻断剂的最好来源.众所周知，抑郁症(depression)为心境障碍的一种临床症状，以显著而持久的心境低落、思维迟缓、认知功能
目的：芋螺毒素因其种类繁多,结构新颖,选择性强,疗效确切,并在镇痛、成瘾、麻醉等方面具有极好的应用前景.本实验室发现了结构新颖的αO-芋螺毒素GeXIVA,是迄今α9α10乙酰胆碱受体(nAChRs)的活性最强的选择性阻断剂.GeXIVA还是第一个电压依赖性的α9α10nAChRs强阻断剂,其半阻断剂量(IC50)在普通ND96缓冲环境中仅为4.6 nM,在Ba2+-ND96环境中为3.8 nM.
目的：海南产αO-芋螺毒素GeXIVA是神经型乙酰胆碱受体(nAChRs) α9α10亚型的特异性强阻断剂.研究发现,α9α 10 nAChR是一些人类疾病的重要靶点,如：治疗神经痛、癌症化疗、乳腺癌、肺癌、伤口愈合等.GeXIVA在CCI神经痛模型上具有极强的镇痛活性,可肌肉注射,是极难得的治疗神经痛的候选新药.GeXIVA含有4个半胱氨酸(Cys,C),其半胱氨酸模式为C-C-C-C,有2中可
烟碱型乙酰胆碱受体(Neuronal nicotinic acetylcholine receptors,nAChRs)是一类广泛分布于中枢及外周神经系统的配体门控离子通道受体.α6β2*nAChRs是其中重要的一种亚型,其作用与尼古丁成瘾、运动功能性障碍相关,是研究和治疗相关疾病的重要靶点.α-芋螺毒素(Conotoxin,CTx) TxIB是从海南产织锦芋螺(Conus textile)中发现
BmK I (an-like toxin purified from the venom of Eastem Asian scorpion Buthus martensi Karsch) has been identified to a site-3 specific modulator of VGSCs with capacity of inducing convulsive motor act
The large-conductance calcium-activated potassium (BK) channels distributed in both excitable and non-excitable cells are key participants in a variety of physiological functions.Martentoxin (MarTX),
Voltage-gated sodium channels (VGSCs) in primary sensory neurons play a key role in transmitting pain signals to the central nervous system.BmK I, a site-3 sodium channel-specific toxin from scorpion
The venom of spider is an increasingly valuable library to discover novel componentsfortherapeutic applications and investigating the relationship of the structure-function of ion channels.The gene of
Serotonin (5-HT), a neuroactive substances, play an important role in the descending inhibitory and descending facilitation system.5-HT receptors, especially 5HT-2A receptor, showed dual-directional r
Dopamine, a kind of catecholamine neurotransmitter, is indispensable to pain responses.Multiple evidences demonstrated that dopamine D2 receptor (DRD2), gap junction and glia may participate in regula