A breakthrough in the understanding of gene expression came with the realization that cells use RNA-guided search engines to identify and regulate both the DNA and other RNAs.First identified in a simple worm C.elegans as "RNA-interference"(RNAi), mechanisms related to RNAi have now been discovered in all domains of life.In RNAi-related mechanisms short pieces of genetic code in the form of RNA serve as search queries allowing the cell to rapidly identify and regulate genes in much the same way you type a short query into Google.Scientists can now enter synthetic RNA search queries into cellular search engines called Argonautes, and recently CAS9/CRISPR, allowing them to precisely cut any cellular RNA or DNA.The result is an unprecedented revolution in molecular genetics that promises to help unlock the secrets of life, and to speed the discovery of new medicines.This talk will describe how organisms use these remarkable mechanisms to program gene expression, and how scientists and physicians are learning to use them as tools.But, what this talk is really about is the excitement of science and the ever unfolding and deepening mysteries of life.