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Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies in Asia and especially in China,and metastasis remains the cause of about 90 %of deaths from HCC.How HCC invade and spread remains a mysterious [1].To understand systematically the earlier events of HCC metastasis,4 HBV induced hepatocellular carcinoma cell lines (MHCC97L,MHCC97H,HCCLM3 and HCCLM6) [2] with the same genetic background and progressive metastatic abilities were selected for transcriptome and proteome investigation synchronously.Data sets of other HBV-induced hepatocellular carcinoma cell lines with (SNU449 and SNU475) and without (Hep3B and SNU398) metastasis ability were also integrated.