Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies in Asia and especially in China,and metastasis remains the cause of about 90 ％of deaths from HCC.How HCC invade and spread remains a mysterious [1].To understand systematically the earlier events of HCC metastasis,4 HBV induced hepatocellular carcinoma cell lines (MHCC97L,MHCC97H,HCCLM3 and HCCLM6) [2] with the same genetic background and progressive metastatic abilities were selected for transcriptome and proteome investigation synchronously.Data sets of other HBV-induced hepatocellular carcinoma cell lines with (SNU449 and SNU475) and without (Hep3B and SNU398) metastasis ability were also integrated.