Diabetes is a complex disease with heterogeneity in disease phenotype,variable patient response to treatment and possible risk associated with particular therapeutic strategies.The latest guidelines from professional organizations including the ADA and EASD have highlighted the need for more personalized treatment strategies compared to the "one-size-fits-all" approach of old.Recent advances in genomewide association studies have led to the identification of more than 70 common genetic variants associated with type 2 diabetes,and a similar number for obesity.