【摘 要】
：
Disordered lipid metabolism is always closely linked to inflammation.However,mechanisms of coordinate regulation of lipid metabolism and inflammation are unknown.Oxygenated cholesterols,oxysterols,app
【机 构】
：
Virginia Commonwealth University McGuire Veterans Affairs Medical Center USA
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Disordered lipid metabolism is always closely linked to inflammation.However,mechanisms of coordinate regulation of lipid metabolism and inflammation are unknown.Oxygenated cholesterols,oxysterols,appear to be the key regulatory molecules involved in lipid metabolism and inflammation.When cholesterol delivered to mitochondria was increased by overexpression of the transporter StarD1 in hepatocytes,oxysterols,a novel regulatory oxysterol,5-cholesten-3,25-diol 3-sulfate (25HC3S),were accumulated in the nuclei.Addition of 25HC3S to hepatocytes and macrophages in culture markedly decreased nuclear liver oxysterol receptor (LXR) protein levels but increased nuclear peroxisome proliferator-activated receptor gamma (PPARg) levels,followed by dose-and time-dependent decreases in nuclear sterol response element binding protein-1 (SREBP-1) protein and its mRNA levels.25HC3S also led to a decrease in the expression of SREBP-1 responsive genes including acetyl CoA carboxylase-1 (ACC-1) and fatty acid synthase (FAS),key enzymes involved in fatty acid synthesis with a subsequent decrease in intracellular lipid levels.
其他文献
A large amount of experimental data on the effects of the nonsteroidal anti-inflammatory drugs (NSAIDs) on cyclooxygenase-1,2 (COX-1,2) have revealed a significant variability in IC50 and COX-1/COX-2
Drug transporters are membrane proteins involved in the uptake or efflux of drugs by several tissues such as the intestine,liver,kidney and brain.They can have a significant impact on the pharmacokine
Tremorgenic neuromycotoxicosis caused by extrolites from several Penicillium species (e.g.Penicillium crustosum) is an important syndrome in domestic animals.The potential hazard to humans remains unc
Cell lines are renewable and constitute an invaluable resource of central nervous system cell types for studies of news therapeutical agents against diseases of CNS.We have determined that flavonoids
For over three decades,controlled drug delivery by magnetic force,as exemplified by magnetic nanoparticles,has been of great interest,simply because it is relatively easy to apply a magnetic force ext
The main goal of the cancer research is to improve the clinical outcome of cancer patients.At present,we can perform tailor-made chemotherapy,the selection of effective chemotherapy based on evaluatio
CDC25 phosphatases are key actors in cyclin-dependent kinases activation whose role is essential at various stages of the cell cycle.CDC25 expression is upregulated in a number of human cancers.CDC25
Cigarette smoking is a major cause of lung cancer; however,it has been difficult to reproduce the tumorigenicity of cigarette smoke in preclinical animal models.Increased lung tumorigenicity has previ
Molecular targets for anti-cancer drugs have emerged from the accumulated evidence obtained by a huge number of the studies in oncology during more than recent three decades.These molecular-targeted a
Cancer is a complex disease resulting from perturbations in multiple regulatory intracellular systems leading to an overall increase in cell number and thus tumor formation.As cancer is a multifactori