【摘 要】
：
To observed the effect of EGb 761 against myocardial fibrosis and its mechanisms.After exposure to aldosterone and EGb 761, cell cycle, proliferation, ET-1 expression, collagen and endothelin (ET) con
【机 构】
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Department of Cardiology,Second Hospital of Hebei Medical University,Shijiazhuang 050000,China
【出 处】
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International Conference for Physiological Sciences 2012(201
论文部分内容阅读
To observed the effect of EGb 761 against myocardial fibrosis and its mechanisms.After exposure to aldosterone and EGb 761, cell cycle, proliferation, ET-1 expression, collagen and endothelin (ET) content in culture medium were measured by flow cytometry, MTT, Western blot, hydroxyproline content and radioimmunoassay,respectively.Aldosterone changed cell cycle, increased proliferation, ET-1 expression, collagen and ET contents,which were inhibited by EGb 761.Our results indicated that EGb 761 alleviated myocardial fibrosis by inhibition of proliferation, collagen synthesis, ET-1 expression and improvement of cell cycle.
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