【摘 要】
:
目的 研究食物中磺胺间甲氧嘧啶(SMM)残留可能对哺乳期小鼠血清胰岛素(INS)、甲状腺素(T3、202T4)、胰岛素样生长因子(IGF-1)和生长激素(GH)以及血糖的影响。方法 成年孕
【机 构】
:
安徽医科大学公共卫生学院营养与食品卫生学系
论文部分内容阅读
目的 研究食物中磺胺间甲氧嘧啶(SMM)残留可能对哺乳期小鼠血清胰岛素(INS)、甲状腺素(T3、202T4)、胰岛素样生长因子(IGF-1)和生长激素(GH)以及血糖的影响。方法 成年孕鼠正常喂养直到自然分娩,分娩后,随机保留仔鼠40 窝。母鼠随机分入对照组(生理盐水)(Control)、低剂量SMM(10mg/kg·day)处理组(Low)、中剂量SMM(50mg/kg·day)处理组(Middle)、高剂量SMM(200mg/kg·day)处理组(High),分娩后第1 天开始,母鼠分别灌胃给予生理盐水和10、50、200 mg/kg SMM(溶于生理盐水),染毒至仔鼠出生后第21 天,采集其血清。用罗氏血糖仪测定小鼠血糖值。用放射免疫法测定血清INS,T3,T4,IGF-1 和 GH 浓度。
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