Aptamers Modified with D-L-Isonucleoside and their Structure and Function Studies

来源 :第五届中国小核酸技术与应用学术会议 | 被引量 : 0次 | 上传用户:Tiramisu_smile
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) was reported to be participated in variety of tumors development.Previously,we isolated an hnRNP A1-specific DNA aptamer BC15,that can evaluate hnRNP A1 expression in liver cancer and inhibit hnRNP A1,which could be a potential drug candidate for hepatocarcinoma treatment.
其他文献
会议
会议
  Metastasis-associated lung adenocarcinoma transcript 1(Malat1)is an example of a functional long noncoding RNA involved in many biologic processes.However,t
会议
会议
Gene therapy is one of the potential methods in treating genetic diseases and some kinds of cancers[1,2].Gene delivery is the process of introducing exogenous n
会议
  RNA activation(RNAa)is a phenomenon of up-regulation of gene expression by small activating RNAs(saRNAs).Using the progesterone receptor(PR)gene as a model,
会议
当今世界石油储量正在日益减少。作为不可再生的化石能源,未来经济的健康持续发展不可能继续依赖石油为主要的能源和化工原料的来源。天然气资源储量丰富,近年来又不断有新的天
为了充分利用有限的石油资源,对重质油进行深度加工是目前炼油和石化企业的重要课题之一。本论文针对重质油资源的利用,在气化和重质烃裂解技术的基础上,探索将重质烃气化一裂解
本文对黑龙江柳树河油页岩、海南省长坡油页岩、内蒙古油页岩和巴西油页岩进行了实验研究,探讨了油页岩含油率与挥发分、灰分和热值之间的相关性,油页岩与半焦的固定碳之间的关