Sheath blight(SB),caused by necrotrophic fungus Rhizoctonia solani Kühn(R.solani),gives rise to severely grain losses in rice.Although various resistance levels of rice varieties to SB have been reported,the underlying resistance mechanism remains largely unknown due to lack of enough information on candidate genes/pathways.In this study,an integrated approach was employed to try to uncover potential mechanism of rice resistance to SB.To reveal the molecular mechanism of riceresponse to R.solani and mine the candidate genes/pathways regulating rice sheath blight(SB)resistance through transcription and metabolite profiling and genetic mapping.