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The cardiovascular side effects of cyclooxygenase-2 (COX-2) inhibitors have prompted scientists to try to find new ways to inhibit the production of pro-inflammatory prostaglandins (PGs),such as PGE2.Blockade of the inducible PGE2 terminal synthase,mPGES-1 (membrane-associated PGE2 synthase-1),is one such approach.