【摘 要】
：
The lysomal cathepsin S (Cat S) has been associated with several types of cancers in humans.However,thus far no report has linked Cat S to the prevalent human hepatocellular carcinoma (HCC).Here we in
【机 构】
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Institute of Bioengineering and Nanotechnology Singapore
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
The lysomal cathepsin S (Cat S) has been associated with several types of cancers in humans.However,thus far no report has linked Cat S to the prevalent human hepatocellular carcinoma (HCC).Here we investigated the expression of Cat S in human normal and HCC livers using methods of immunohistochemistry and Western blot.The results showed that no or very low level of Cat S was detected in the hepatocytes of normal livers.In contrast,a significant increase in the Cat S expression was detected in the cancerous hepatocytes in 34 of the total 63 HCC livers (54%; P<0.01).The Cat S positive rate was significantly higher in the HCC nodule than in the peri-nodular region (P<0.01).Nevertheless,the Cat S positive rate in the peri-HCC region was still significantly higher than in the normal liver tissue (P<0.01).The elevated Cat S expression in the HCC was positively correlated with the presence of portal vein tumor thrombus (P<0.01),extra-hepatic metastasis (P<0.05),and the degree of de-differentiation (P<0.01),but not correlated with age,the presence of HBsAg and cirrhosis,the level of serum alpha-fetoprotein (AFP),the number of tumor nodules,the tumor size,and the clinical stage (P>0.05).The aberrant over-expression of Cat S in the cancerous hepatocytes could be one of the key events involved in HCC tumorigenesis,invasion,and metastasis.
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