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The Chemokine receptor 4(CXCR4),overexpressed in many malignant tumors,In recent years,many studies have shown that CXCR4 plays an important role in tumor metastasis.Therefore,it is emerging as an attractive target for cancer therapy.In the present study,the single-chain variable fragment(scFvs)against CXCR4 were screened by yeast two-hybrid technique and examined the inhibitory effects of anti-CXCR4 antibodies in tumor cells in vitro.