【摘 要】
：
Irinotecan-induced severeneutropenia and diarrhea which are still unpredictable hasrestrained the dose and clinical efficiency of itself.A total of 70 Irino
【机 构】
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CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy
【出 处】
：
The 4th International Conference of Genomics Beyond Biologic
论文部分内容阅读
Irinotecan-induced severeneutropenia and diarrhea which are still unpredictable hasrestrained the dose and clinical efficiency of itself.A total of 70 Irinotecan-treated patients with histologically confirmed metastatic gastrointestinal cancer were included in ourstudy.Despite of genotyping hot-reported alleles identified abroad,we specifically adopteddirect sequencing to avoid the ethnic heterogeneity and to identifynovel variations.We sequenced the promoter(-1000bp)and exon 1 regions of UGT1A1,UGT1A7 and UGT1A9,and performed comprehensive analysis of their genetic polymorphisms to determine the correlation between inherited genetic variations and toxicity Irinotecan-induced.
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