【摘 要】
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Recent studies have revealed that heterocycles containing P-substituents show unique bioactivities and chemical properties,which lead them to a broad applicatio
【机 构】
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SchoolofChemistryandChemicalEngineering,SouthChinaUniversityofTechnology,Guangzhou,510640
【出 处】
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第五届岭南有机化学论坛暨华南理工大学-兰州大学有机化学双边论坛
论文部分内容阅读
Recent studies have revealed that heterocycles containing P-substituents show unique bioactivities and chemical properties,which lead them to a broad application in organic synthesis,medicinal chemistry and materials chemistry.In light of their importance,various approaches to construct C-P bonds on heterocycles by transition metal-catalyzed coupling reactions[1] or radical cascade reactions[2] have been reported these years.However,by-products were unavoidable in these processes and synthetic methods of phosphorylated furans from alkenes or alkynes have been less explored up to now.In order to expand the richness of green synthetic methods,we developed an efficient and highly regioselective strategy for the synthesis of phosphorylated furans via Cu-catalyzed Csp3-P bond construction between ene-yne-ketones[3] with H-phosphonates[4].This method features inexpensive metal catalysts,no usage of oxidant,good functional group tolerance and high atom economy(Scheme 1).
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