Protective effect of 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1,4-dione, isolated from Averrhoa caram

来源 :第十二届中国实验动物科学年会 | 被引量 : 0次 | 上传用户:moowoo
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  Objective studies have demonstrated that 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD),isolated from the roots of Averrhoa carambola L.,has significant therapeutic potential for the treatment of diabetes.However,the protective effect of DMDD against pancreatic beta cell dysfunction has never been reported.We investigated whether DMDD protected against palmitic acid-induced dysfunction in pancreatic β-cell line Min6 cells by attenuating the inflammatory response and apoptosis and to shed light on its possible mechanism.
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