Wilsons disease (WD) is an uncommon autosomal recessive and metabolic disorder occurring due to excessive deposition of copper in many tissues, particularly the basal ganglia of the brain, the cornea, and the liver, which manifests as neurological or psychiatric symptoms and liver disease.In the present study, we focus on WD patients with brain disorder using resting state functional resonance imaging (fMRI) technique to explore the dysfunction of their brains.However, as a basal ganglia disorder the neurological mechanism of WD remains largely unknown.It has been demonstrated that the WD patients had deficits in alerting function,examined by attention network test (ANT), and the attention function has been associated with posterior cingulate cortex (PCC) and default mode network (DMN).