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Background Acute fatty liver of pregnancy (AFLP) can lead to fatal liver damage that occur in the third trimester or early postpartum period.The effect of traditional therapy is not very ideal for facilitating hepatic recovery.The safety and effect ofnon-bioartificial liver (NBAL) in application for treating AFLP are lacking systematic introduction.Aim Analysis of the timing and efficacy of non-bioartificial liver (NBAL) in the treatment of acute fatty liver of pregnancy (AFLP).Methods We observed the clinical data of 5 cases of AFLP treated with NBAL from 2007 to 2012 including symptoms, physical signs, adverse effects, and compared all relevant laboratory test results before and after NBAL.Results (1) Side effects during NBAL were slight and well-tolerated, and no patients interrupted treatment because of negligible side effects; Clinical symptoms, signs, and liver and renal functions can be ameliorated significantly after NBAL; (2) In the 5 cases treated, 4 were cured, 1 succeeded in bridging to transplantation; (3) In the 4 cases cured, the sooner a AFLP patient received NBAL the better the curative effect.Conelusion Treatment of AFLP by NBAL is safe and effective, and early application of NBAL in AFLP patients can effectively treat and reverse progress of the disease.