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Since the introduction of the first probe,numerous small-molecule probes have been well established as important toolkits for the consideration of the biological processes,medical diagnosis,biological imaging at the molecular,cellular and organism level.Compared with other techniques,small-molecule fluorescent and bioluminescent probes could provide dynamic information in the real-time and spatial-temporal resolution,as well as minimal influence of the target protein properties.So far,small molecule probes have comprehensively facilitated to track down various biotargets such as proteins and bioactive small molecules.