【摘 要】
：
Circulating tumor cells (CTCs) have become an emerging "biomarker" for monitoring cancer metastasis and prognosis.Although there are existing technologies available for isolating/counting CTCs,the mos
【机 构】
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Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China
【出 处】
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第八届全国微全分析系统学术会议、第三届全国微纳尺度生物分离分析学术会议暨第五届国际微化学与微系统学术会议
论文部分内容阅读
Circulating tumor cells (CTCs) have become an emerging "biomarker" for monitoring cancer metastasis and prognosis.Although there are existing technologies available for isolating/counting CTCs,the most common of which using immunomagnetic beads,they are limited by their low capture efficiencies and low specificities.By introducing a three-dimensional (3D) nanostructured substrate – specifically,a silicon-nanowire (SiNW) array coated with anti-EpCAM – we can capture CTCs with much higher efficiency and specificity.The conventional methods of isolating CTCs depend on biomolecular recognitions,such as antigen-antibody interaction.Unlikely,we here proposed that nanoscaled local topographic interactions besides biomolecular recognitions inspired by natural immuno-recognizing system.This cooperative effect of physical and chemical issues between CTCs and substrate leads to increased binding of CTCs,which significantly enhance capture efficiency.Recently,we have also developed a 3D cell capture/release system triggered by aptamer enzyme,which is effective and of "free damage" to capture and release cancer cells.The bio-inspired interfaces of cell capture and release open up a light to rare-cell based diagnostics,such as CTCs,fetal cells,stem cell and so on.
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