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The pathogenesis of hepatitis B-related liver failure is complicated,and there is no effective treatment method at present.Glucocorlicoid can inhibit the immune reaction,reduce the production of inflammation medium,and also has strong and rapid effect on anti-endotoxin,at the same time glucocorticoid can stabilize the lysosome membrane,protect the liver cell,and reduce the necrosis of liver cell.Glucocorticoids has been widely used in clinical practice by its unique biological charactaristics.In this paper,the research progress of glucocorticoid treatment for hepatitis B-related liver failure is discussed.