The surface gap junction SGJ directly connects the cytoplasm of two cells, allowing various molecules and ions to pass freely between the cells.In granulose cells GC the SGJ allow the passage of the oocyte meiotic inhibitor OMI to arrest the division in the prophase stage.An increase in the number of the SGJ between the GC was reported to be affected by the level of the FSH.Aim: The present work aimed to study the granulose cell junctions at the different staged of follicular development.