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The proliferation,migration and inflammation of vascular smooth muscle cells(VSMCs)contributes to the pathogenesis and progression of several cardiovascular diseases such as atherosclerosis and hypertension.Angiotensin(Ang)-(1-7)and Angiotensin(Ang)Ⅱ are identified to be two bioactive peptides of renin-angiotensin system(RAS)which are involved in regulating the cardiovascular activity.