Perifosine was shown to have a profound anti-tumor activity paired with a favourable toxicological profile.Mechanistically, the inhibition of tumor cell growth by Perifosine is based on a variety of effects, including inhibition of tumor cell invasion, induction of cell differentiation, apoptosis and inhibition of angiogenesis.A key feature of Perifosine is the consistent inhibition ofAkt phosphorylation in most tumor cell lines studied.Blocking in the Akt phosphorylation is necessary for the activation of downstream targets, including mTOR.As a constitutively activated PI3K /Akt / mTOR pathway was identified as one of the elements which is causal for tumor growth and survival in many tumor entities, blocking the Akt activity by Perifosine might represent a promising option in the future tumor treatment.