Tissue metabonomics is a systemic method to study the biological state and function regulation of organisms by analyzing the metabolites fingerprint.The changes of the metabolites fingerprint of the mice with transplanted tumor aroused by different medicines are analyzed by tissue metabonomics methods to see the inhibition mechanism of the Siweigantai Soft Capsule on the transplanted tumor.80 healthy female Kunmin mice (SPF) were divided into nine groups, including blank control, model, 2 positive control groups, and 5 administration groups.The hepatocarcinoma cells H22 were injected into the armpits of the mice in model group, positive control groups and administration groups.