Background: Multisegmental cervical spondylotic myelopathy (CSM) is difficult to treat because it is a complicated condition which causes irreversible spinal cord injury.Objective: To investigate the clinical characteristics and management of CSM involving more than three levels.Methods: Forty-five patients with CSM were included in this retrospective study; their ages ranged from 37 to 72 years.Seventeen (37.8%) patients had noncontiguous or "jumping" multisegrnental CSM and 28 (62.2%) had contiguous multisegmental CSM.In 37 patients the lesion involved three functional segments; in 7 patients, the lesion involved four functional segments and in 1 patient the lesion involved five functional segments.The mean preoperative Japanese Orthopedic Association (JOA) score was 8.1 points.All patients underwent combined single-level decompression of the involved intervertebral space and subtotal corpectomy together with subsequent fusion and internal fixation.An anterior approach was used.A cage filled with bone graft was inserted and internal fixation was performed after single-level intervertebral space decompression.Mesh filled with bone graft was inserted and plate internal fixation was performed after subtotal corpectomy.A Philadelphia cervical collar was applied for 3 months after the operation.Results: Twelve-month follow-up data were available for all 45 patients; the mean postoperative JOA score was 13.2 points, bony fusion was achieved in all cases, and no pseudoarthrosis was observed.Conclusion: Although CSM is a very complicated condition, combined single-level subtotal corpectomy and decompression of intervertebral space can achieve an excellent outcome.