一系列多胺修饰环糊精衍生物对喜树碱的键合行为研究

来源 :全国第十七届大环化学暨第九届分子化学学术讨论会 | 被引量 : 0次 | 上传用户：qwaszxzx

【摘要】

：

引言喜树碱(Camptothecin,CPT)是从中国特有的珙桐科植物喜树中分离出的一种吲哚类生物碱,它能通过抑制拓扑异构酶而使肿瘤细胞死亡,为广谱抗肿瘤药物.在溶液中CPT 通常有两

【作者】

：

王倩张旭杰王征刘育

【机构】

：

天津商业大学化学系天津市北辰区津霸公路东口300134南开大学化学系元素有机化学国家重点实验室天津市南开区卫津路94号300071

【出处】

：

全国第十七届大环化学暨第九届分子化学学术讨论会

【发表日期】

：

2014年8期

【关键词】

：

喜树碱环糊精分子键合水溶性

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

引言喜树碱(Camptothecin,CPT)是从中国特有的珙桐科植物喜树中分离出的一种吲哚类生物碱,它能通过抑制拓扑异构酶而使肿瘤细胞死亡,为广谱抗肿瘤药物.在溶液中CPT 通常有两种存在形式,即闭环内酯形式(Ⅰ)和开环后的羧酸盐形式(Ⅱ)(如图1 所示),前者能够有效抑制拓扑异构酶,而后者表现出极低的抗拓扑异构酶活性,且有较大毒副作用.

其他文献

Polymer nano-structures fabricated and observed by electron microscopy

In order to realize novel functional surfaces,polymers chemically grafted to the surface of substrates,known as polymer brushes,are often used to modify surface

会议

DISEASE-INSPIRED MATERIALS

The usual science and technology approach to disease is "We must cure it!" But mo lecular devices and processes that bring an end to life are powerful things to

会议

π-Stack Control in Perylene-based Discotic Liquid Crystals

Discotic columnar liquid crystalline (DCLC) materials with a conjugated core are attractive due to their excellent processability and unique advantages such as

会议

RHEOLOGY OF POLYMER-GRAFTED NANOOBJECTS WITH DIFFERENT SHAPES

　　Polymer-grafted nanoobjects(PGNOs)are a kind of nanoparticles with persistent geometric shape and densely tethered polymer hairs.[1] They are very important

会议

PREPARATION OF MICROPOROUS POLYAMIDE NETWORKS FOR CARBON DIOXIDE CAPTURE AND NANOFILTRATION

　　For the first time,microporous polyamide networks were synthesized via interfacial polymerization of piperazine and acyl chloride monomers containing tetrah

会议

Tetraphenylmethanetetraphenylsilanemicroporous polyamidesinterfacial polymeri

Kinetics pathway in the phase separation and crystallization of iPPOBC blends

　　Mesophase separation between the incompatible blocks in multiblock copolymers OBC(Olefin Block Copolymers),coupled with the macrophase separation in its ble

会议

Studies on Polymeric Hierarchical Microstructures and Their Properties

Self-assembly of polymers into hierarchical microstructures has attracted much attention in recent years.[1] It has been reported that multiblock copolymers and

会议

SELF-ASSEMBLY OF AMPHIPHILIC DIBLOCK COPOLYMERS IN SELECTIVE SOLVENTS A SIMULATION STUDY

Self-assembly of block copolymers has attracted considerable attention for many decades because it can yield ordered structures in a wide range of morphologies,

会议

POLYOXOMETALATE-POLYHEDRAL OLIGOMERIC SILSESQUIOXANES -POLYMER HYBRIDS SYNTHESIS, STRUCTURE AND FUNC

In the past years we focused on creating a class of the novel functional hybrids composed of polyoxometalates (POMs),polyhedral oligomeric silsesquioxanes (POSS

会议

羧酸咔咯与DNA的相互作用

DNA 是生物体内重要的遗传物质,研究化合物与DNA 的相互作用对DNA 探针、靶向抗癌药物和人工模拟核酸酶等开发均有重要意义[1-3].近年来,咔咯与生物大分子的相互作用研究引起

会议

咔咯DNA作用模式

一系列多胺修饰环糊精衍生物对喜树碱的键合行为研究

与本文相关的学术论文