Our recent studies have shown that the inferior collicular (IC) neurons of constant frequency-frequency modulation (CF-FM) bats could be classified into single-on (SO) and double-on (DO) responders ac
There is now mounting evidence implying the involvement of retinal dopamine (DA) in the signaling cascade that leads to myopic eye growth.Surprisingly,in one of our recent work,retinal DA levels are f
Rotenone,a common pesticide and inhibitor of mitochondrial complex I,induces loss of dopaminergic neurons and consequential aspects of Parkinsons disease (PD).However,the exact mechanism of rotenone n
本研究将心房钠尿肽(ANP)的羧基端分别与脑钠尿肽(BNP)及C 型钠尿肽(CNP)的环状结构和氨基端进行不同的组合，设计、合成并筛选出活性最高的NPs 嵌合体CNAAC(CNP 氨基端+ANP 环+ANP 羧基端)。通过离体和在体实验，观察CNAAC 的舒血管、利尿作用及其对缺血性心衰大鼠心脏结构和功能的影响。
Parkinsons disease(PD)is a common neurodegenerative movement disorder affecting an increasing number of elderly.Various studies have shown that mitochondrial dysfunction and abnormal protein aggregati
OBJECTIVE:The crosstalk between mTORC1/S6K1 signaling and AMPK is emerging as a powerful andhighly regulated way to gauge cellular energy and nutrient content.The aim of the current study was toelucid
The loss of dopaminergic neurons in the substantia nigra pars compacta contributes the characteristic motor symptoms of Parkinsons disease (PD):bradykinesia,rigidity and resting tremors.Although dopam
Striatal dopamine (DA) release can be independently triggered by two pathways,the midbrain nigrostriatal ascending pathway and the cholinergic transmission-induced dopaminergic transmission (CTDT) pat
急性移植物抗宿主病(acute graft versus host disease,aGVHD)是影响异基因造血干细胞移植(allogeneichaematopoietic stem cell transplantation,allo-HSCT)成功的主要并发症,也是移植相关死亡的最主要原因之一。近年来随着对aGVHD 病理生理机制及细胞因子网络的阐明,由此产生了新的预防与治疗策略。
Histone deacetylases (HDACs) and microRNAs (miRNAs) have emerged as two important epigenetic factors that regulate vascular physiology,but there is a lack of information linking them to vascular disor