Syntheses of (+)-Sertraline and (+)-Indatraline Using CSI-mediated Stereoselective Amination in the

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户:q365709285
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The regioselective and diastereoselective allylic amination of allylic polybenzyl ethers using ehlorosulfonyl isoeyanate (CSI) are powerful methods for the preparation of α-amino-β-hydroxy acids and five or six-membered heteroeyele compounds.These reactions have been used as key transformations for the syntheses of natural products such as (-)-lentiginosine, DAB, DGDP, deoxoprosophylline and deoxynojirimycin analogues.
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