TRP Ion Channels as Promising Therapeutic Targets

来源 :2014第五届国际神经科技大会暨2014首届国际高科技针灸和中西医结合大会 | 被引量 : 0次 | 上传用户:yangzexv001
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Transient receptor potential (TRP) ion channels have been extensively investigated over the past few years and they are being ardently pursued as targets for drug discovery.Several factors make TRP ion channels for appealing as drug targets.First, they are the largest group of noxious stimulus detectors in pain receptors (nociceptors).Second, although pain is currently the most advanced TRP channel-related field, an increasing number of gene deletion researches in animals and genetic association studies in humans have demonstrated that the pathophysiological roles ofTRP charmels extend well beyond the sensory nervous system.
其他文献
Disc degeneration is an extraordinary common patology among human kind that can generate back or radicular pain.90% of the patients response to either physical therapy or medical treatment, though 10%
会议
Neurosurgical diseases like brain tumors and vascular malformations as well as spinal tumors usually become symptomatic and require microsurgical removal.However in some cases these pathologies are fo
会议
Verbal processing speed is one of the most frequent cognitive deficits associated with traumatic brain injury (TBI).Verbal processing speed deficits affects verbal memory.This study investigated a neu
会议
Glioblastoma (GBM) is an aggressive, malignant brain tumor that is highly heterogeneous and often resistant to chemotherapy and radiation treatment.The median survival time of patients with GBM is 12-
会议
The incidence of traumatic brain injury (TBI) is approximately two million Americans per year, causing inflammatory, stroke and seizure.Although the characteristic activity in the epileptic cortex aft
会议
Neuronal Calcium Sensor (NCS) proteins comprise a family of proteins that determine response to calcium fluctuations.Their role in normal physiological functions such as photo/visual transduction and
会议
Purpose: The aim of the present study is to determine whether Tamoxifen causes attenuation of traumatic brain injury (TBI) induced depression-like behavior induced by fluid percussion injury (FPI).Mat
会议
Alzheimers disease (AD) is a devastating neurodegenerative disease for which no cure (other than palliative) exists.The search for cure demands knowledge of the early pathological changes-critical nec
会议
Recently there has been increased interest in neural biomarkers and the understanding the brains functional connectivity across local and tong-range networks.While structural and functional connectivi
会议
New research criteria have been developed that define three principal phases in Alzheimers disease: Preclinical, Mild Cognitive Impairment, and dementia.These criteria consider the cognitive and bioma
会议