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Anti-angiogenesis has become a novel strategy for cancer therapy.Chinese herbal medicine is being paid more and more attention as an alternative way for cancer prevention and treatment.The objective of this study was to explore the antiangiogenic effects and mechanisms of Spatholobus suberectus Dunn(SS) extracts in vitro and in vivo.The results demonstrated that SS inhibited both VEGF production in cancer cells and the proliferation of endothelial cells, as well as tumor formation and invasion ability in a VEGF independent manner.In vivo study also indicated that SS could inhibit tumor angiogenesis.In conclusion, SS is a promising herb as a potential anti-angiogenesis for cancer therapy.