Gram Scale Synthesis of Key Intermediate of Taiwaniaquinoids

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户:XIEJUANJUAN1984
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
A gram scale approach was developed toward the advanced intermediate of taiwaniaquinoids.This intermediate 5a with trans A/B ring junction was concisely assembled by employing a Bi(OTf)3-catalyzed cationic cyclization and a Wolff-type ring contraction as key steps.The above sequence scaled reliably, and 1 g of 5a was readily prepared.This common intermediate was readily converted to racemic taiwaniaquinones A and F and taiwaniaquinols B and D, respectively.
其他文献
A systematic study on the biological activity of pyrrolopyrimidinesas epidermal growth factor receptor (EGFR) inhibitors has been performed.[1] This has led to severalcompounds showing low nanomolar a
会议
The first catalytic asymmetric isatin-involved Povarov reaction has been established.This method provides an unprecedented approach to access enantioenriched spiro[indolin-3,2-quinoline] scaffold with
会议
Previously, the multicomponent reactions of enaminones 1, aldehydes and amines have been found to generate symmetrical 1,4-dihydropyridines (1,4-DHP) 2 (eq 1).[1] In present work, we achieved three-co
会议
An efficient synthetic method has been developed to construct benzo[b]naphtho[2,1-d]thiophene (2) via Au-catalyzed cyclizayion reaction.Treatment of 2-[2-(2-alkynylphenyl)ethynyl]thioanisole (1) under
会议
The indole alkaloids, ranging from lysergic acid to vincristine, have long inspired organic chemists.Interest in developing new methods for indole synthesis has burgeoned over the past few years.1 Usa
会议
Chalcones, pyrazoles and pyrimidine derivatives are known to be good antibacterial agents.[1] A series of pyrimidine analogues of triazole linked chalcone and pyrazole have been synthesized from 5-ace
会议
A chiral gold(Ⅰ) complex-catalyzed highly regio-and enantioselective azo hetero-Diels-Alder reaction has been developed.The chiral gold(Ⅰ) complex acting as a Lewis acid exhibits high efficiency in th
会议
A synthesis of 2-epi-fagomine via a highly stereoselective gold(Ⅰ)-catalyzed allene cyclization is described.The stereochemical outcome of the cyclisation is opposite to that observed in previous stud
会议
An enantioselective organocatalytic addition of nitroalkanes to oxindolylideneindolenines in the presence of bifunctional organocatalysts has been established to provide an efficient entry to 3,3-disu
会议
The first total synthesis of tubingensin A was finished starting from an advanced intermediate of anominine.The synthesis features a CuOTf-promoted 6π-electrocyclization/aromatization sequence to forg
会议