The slow domino effect modelling framework for the onsetof epileptiform activity

来源 :第四届全国神经动力学学术会议 | 被引量 : 0次 | 上传用户:datangkang123
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Mathematical models of excitable cells,such as neurones,are often characterizedby different dynamic regimes,such as alternating rest and excited(seizure)states.The onsetof an epileptic seizure is an example of a \domino" like transition between states; as eachnode transitions into a seizure state other nodes in the network are sequentially recruited.
其他文献
AMPA 受体主要存在于兴奋性神经元突触中,负责介导中枢神经系统中大部分的快速兴奋性突触传递,它在突触后膜的动态活动中能够诱发和维持长时程增强(long-term potentiation,LTP)和长时程抑制(long-term depression,LTD)作用,进而影响大脑的学习和记忆活动。因此,研究AMPA 受体的输运机制,有助于研究大脑学习和记忆的生理机制,具有重要的科研和实际意义。实验
Although human brain network is widely acknowledged as critical dynamics,the difference between criticality of eyes-open and eyes-close state remains poorly understood.Here we investigated whether the
Astrocytes are critical regulators of normal physiological activity in the central nervous system,and one of their key functions is removing extracellular K+.In recent years,numerous biological studie
Traditionally,there has been a widely accepted notion that the transition from acute to chronic pain follows a linear trajectory,where an injury leads to acute episodes,subacute stages,and progresses
呼吸运动是一种复杂且具有丰富动力学行为的节律性活动,与人类的健康密切相关.病理状态下,往往出现各种呼吸节律的变化.Pre-B(o)tzinger 复合体是哺乳动物呼吸节律起源的关键部位.研究表明,各离子电导(gNaP,gK,gNa)变化可引起神经元混合簇放电.
癫痫发作通常由解剖脑网络中稀疏分布的位点产生,但癫痫产生的脑网络拓扑结构和动力学仍然是一个悬而未决的问题。尽管如此,临床证据表明癫痫脑网络具有小世界特性,如短路径长度和高聚类系数等。此外,神经场模型与临床脑电直接输出相关,且已被广泛研究以阐明癫痫形态节律产生的网络效应。
哺乳动物的大脑皮层中的波动行为对生理活动调节起到至关重要的作用。皮层中的波动不但在规则波动和不规则波动行为之间切换,而且也在不同类型的规则波动转迁。本文采用FHN 神经元网络模型研究螺旋波和矩形波之间的转换。在形成稳定神经斑图之前,首先在较短时间内形成螺旋波和矩形波共存的斑图。在神经元耦合强度小于临界值时,螺旋波区域逐渐缩小而最终形成矩形波。
Object conceptual processing has been localized to distributed cortical regions that represent specific attributes.A challenging question is how object semantic space is formed.We tested a novel frame
自组织临界性指的是处于非稳态的系统在没有外界刺激下自发向稳态转变的性质,研究发现许多脑组织系统都具有类似的性质。默认模式网络(Default mode network,DMN)作为一类特殊脑区的组合,同样具有这种自发转变的性质,但至今DMN 与自组织临界态之间联系依然不明。
The gamma oscillation(30-80Hz)of local field potential(LFP)is activated during some activecognitive states.Some previous work on macaques V1 showed that neural response and gammaoscillation in LFP are