【摘 要】
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Human Parainfluenza virus type 3 (HPIV3) belongs to the Paramyxoviridae family.Its three intemal viral proteins,the nucleoprotein (N),the phosphoprotein (P),and
【机 构】
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StateKeyLaboratoryofVirologyandModernVirologyResearchCenter,CollegeofLifeSciences,WuhanUniversity,Wu
【出 处】
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湖北省细胞生物学学会2015年会员代表大会暨学术研讨会
论文部分内容阅读
Human Parainfluenza virus type 3 (HPIV3) belongs to the Paramyxoviridae family.Its three intemal viral proteins,the nucleoprotein (N),the phosphoprotein (P),and the polymerase (L),form the ribonucleoprotein (RNP) complex,which encapsidates the viral genome and associates with M protein for virion assembly.We previously showed that the M protein expressed alone is sufficient to assemble and release virus-like particles (VLPs),and a point mutant of M protein,ML305A,has a VLP formation ability similar to that of wild-type M protein.In addition,the recombinant HPIV3 containing the ML305A mutation (rHPIV3-ML305A,) could be successfully recovered.Herein,we found that the titer ofrHPIV3-Mt305A was at least 10-fold lower than the titer ofrHPIV3.
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