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Lung cancer has become one of the most common malignant tumors in today's world.It is a high degree of malignancy and was found occult onset and most patients were in late stage.The prognosis of Lung cancer is poor.The effect of chemotherapy drugs used in current clinical is poor with lots of side effects.So it is very important to find efficient and low toxicity durg for lung cancer.Gambogenic acid is one of the main components of gamboges.Current studies have shown that it has anti-tumor effectand is expected to be developed as anti-tumor drug.However, the mechanism of antitumor effect was still uncleared.So to develop Gambogenic acid as a safe and effective anti tumor drug is still need further research.Purpose To study the killing effect of Gambogenic acid on lung cancer cells and its possible molecular mechanism, so that to provide theoretical basis for drug development.