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Atherosclerosis is a chronic inflammatory disease.Hyperhomocysteinaemia (HHcy) accelerates atherosclerosis in ApoE-/- mice by enhancing T cell inflammatory activation.Recent studies have shown that activated T cells adopted into a metabolic switch from oxidative phosphorylation to aerobic glycolysis.Here we sought to determine how metabolic reprogramming contributed to HHcy-induced T cell inflammatory activation.