Myofascial trigger points serve as sources of strong peripheral nociceptive inputs sensitizing central nervous system and inducing motor control failures.Current evidence shows that nociceptive inputs from deep tissues, especially from active myofascial trigger points, induce spinal and supraspinal sensitization, resulting in an enlarged area of mechanical hyperalgesia.Pain induced from active myofascial trigger points reproduces overall pain pattern in fibromyalgia and headache patients, while inactivation of active trigger points attenuates central sensitization and pain sensitivity.In addition, the reciprocal interaction between trigger points in different body segments constitutes a network, mediating pain propagation to deep tissues at the same spinal segment (contralateral side) and extrasegmental levels.A myofascial trigger point represents a dysfunctional and hyperexcitable motor endplate, where an enormously increased release of acetylcholine promotes the formation of taut muscle bands, muscle spasm, and cramps.When a muscle harbors a trigger point, motor functions, such as: movement coordination, fine movement control, and muscle relaxation mechanisms are decreased due to reduced spinal reciprocal inhibition.Further, abnormal movement control strategies overload active muscle fibers close to myofascial trigger points, new trigger points are developed and pain propagates within the same muscle, in the agonists and antagonists.Further research on sensorymotor control mechanisms for pain propagation may provide important clues for the treatment of musculoskeletal and neuropathic pain conditions.