Enhanced anti-proliferative activities and anti-tumor mechanisms of fungal secondary metabolite chet

来源 :中国化学会第十届全国天然有机化学学术会议 | 被引量 : 0次 | 上传用户：aquariuszh

【摘要】

：

【作者】

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Liang Ouyang Chang-Yang Gong Gu He

【机构】

：

State Key Laboratory of Biotherapy & Collaborative Innovation Center of Biotherapy, West China Hospi

【出处】

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中国化学会第十届全国天然有机化学学术会议

【发表日期】

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2014年11期

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Chetomin is a natural product discovered from Chaetomium spp.and has some related fungal secondary metabolites with an unusual bridged disulphide diketopiperazine core.We became interested in chetomin initially because of its potent and selective anti-tumor activity attributable to reactive oxygen species (ROS) induction imposed by inhibition of the redox enzyme thioredoxin reductase and HIF-lα.

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Enhanced anti-proliferative activities and anti-tumor mechanisms of fungal secondary metabolite chet

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