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Objective Gastric cancer is a common and highly fatal malignancy,being the fourth most common cancer and the second leading cause of cancer death in the world.Long noncoding RNAs(lncRNAs)are a class of RNAmolecules with more than 200 bases that function as RNAs with little or no protein-coding capacity.Generally,lncRNAs regulate gene expression at three levels: epigenetics,transcriptional regulation and post-transcriptional regulation,widely involving in the physiological and pathological processes.Accumulating studies have demonstrated that lncRNAs may play an active role in tumorigenesis,metastasis,prognosis and drug resistance of gastric cancer.