APE-1 PLAYS CRUCIAL ROLES IN GAMMA-HERPESVIRUS REACTIVATION AND A PROMISING THERAPEUTIC TARGET FOR D

来源 :17th International Workshop on Kaposi’s Sarcoma Associated H | 被引量 : 0次 | 上传用户：Disama

【摘要】

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KSHV is associated with number of human malignancies.Increasing evidences suggest that lytic cycle of the virus plays important roles in virus-mediated oncogene

【作者】

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Canrong Zhong Yan Wang Yan Yuan

【机构】

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InstituteofHumanVirology,SunYat-senUniversitySchoolofMedicine,Guangzhou,Guangdong510080,ChinaInstitu

【出处】

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17th International Workshop on Kaposi’s Sarcoma Associated H

【发表日期】

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2014年7期

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KSHV is associated with number of human malignancies.Increasing evidences suggest that lytic cycle of the virus plays important roles in virus-mediated oncogenesis.A comprehensive understanding of KSHV lytic cycle will lead to novel strategies to treat KSHV-associated diseases.Here we report that APE-1 protein is critically required for KSHV reactivation and inhibitors of APE-1 effectively inhibit lytic replication of the virus.

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